The impact of air pollution on COVID-19 incidence, severity, and mortality: A systematic review of studies in Europe and North America.

BACKGROUND

Air pollution is speculated to increase the risks of COVID-19 spread, severity, and mortality.

OBJECTIVES

We systematically reviewed studies investigating the relationship between air pollution and COVID-19 cases, non-fatal severity, and mortality in North America and Europe.

METHODS

We searched PubMed, Web of Science, and Scopus for studies investigating the effects of harmful pollutants, including particulate matter with diameter ≤2.5 or 10 μm (PM or PM), ozone (O), nitrogen dioxide (NO), sulfur dioxide (SO) and carbon monoxide (CO), on COVID-19 cases, severity, and deaths in Europe and North America through to June 19, 2021. Articles were included if they quantitatively measured the relationship between exposure to air pollution and COVID-19 health outcomes.

RESULTS

From 2,482 articles screened, we included 116 studies reporting 355 separate pollutant-COVID-19 estimates. Approximately half of all evaluations on incidence were positive and significant associations (52.7%); for mortality the corresponding figure was similar (48.1%), while for non-fatal severity this figure was lower (41.2%). Longer-term exposure to pollutants appeared more likely to be positively associated with COVID-19 incidence (63.8%). PM, PM, O, NO, and CO were most strongly positively associated with COVID-19 incidence, while PM and NO with COVID-19 deaths. All studies were observational and most exhibited high risk of confounding and outcome measurement bias.

DISCUSSION

Air pollution may be associated with worse COVID-19 outcomes. Future research is needed to better test the air pollution-COVID-19 hypothesis, particularly using more robust study designs and COVID-19 measures that are less prone to measurement error and by considering co-pollutant interactions.