小儿囊性纤维化患者尿钠排泄分数（FENa）与生长参数之间的关联。
The association between Sodium Urinary Discharge (FENa) and growth parameters in pediatrics with cystic fibrosis.
作者信息
Reisi Mohsen, Keivanfar Majid, Rezaie Mahboobe, Hovsepian Silva
机构信息
Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.
出版信息
Am J Clin Exp Urol. 2022 Aug 15;10(4):246-251. eCollection 2022.
BACKGROUND
Given the association between chronic sodium losses and growth parameters and establishment of normal weight gain and linear growth in patients with cystic fibrosis (CF), in this study, we aimed to evaluate the sodium status in Iranian CF patients and its association with their growth parameters.
METHODS
In this prospective cross-sectional study, 44 children with CF were included. Serum and urinary sodium and creatinine levels were measured in patients, and the fractional excretion of sodium was calculated. The patients categorized in groups with FENa <0.5%, between 0.5% and 1.5% and >1.5%. Growth parameters were compared in the group, and its association with FENa level was evaluated.
RESULTS
In this study, 44 (27 boys and 17 girls) children with CF were included. Mean age of the studied population was 55.63 (33.2) months. In the studied patients with CF, 90.9% had a z score of -2_+2 (normal range) for BMI, 72.7% for weight, and 70% for height. From children with CF, 18 (40.9%) had FENa less than 0.5, 17 (38.6%) had FENA between 0.5-1.5, and 9 had FENa >1.5. From studied patients with CF, 16 (88.9%) had normal serum Na levels, but the FENa was ≤0.5. Based on the Spearman correlation test, there was not any significant correlation between FENa classification and the Z score of weight (P=0.92), height (P=0.83), and BMI (P=0.99).
CONCLUSION
Our findings indicated that most patients with a low level of FENa had normal serum sodium levels. We did not find a significant association between FENa and growth parameters. The association had a trend to be significant for BMI. It is suggested that it may be due to appropriate follow-up of the studied population. However, it is recommended to plan more studies by including healthy subjects to obtain results that are more accurate.
背景
鉴于慢性钠流失与生长参数之间的关联，以及囊性纤维化（CF）患者正常体重增加和线性生长的建立，在本研究中，我们旨在评估伊朗CF患者的钠状态及其与生长参数的关联。
方法
在这项前瞻性横断面研究中，纳入了44名CF儿童。测量患者的血清和尿钠及肌酐水平，并计算钠的分数排泄率。将患者分为钠分数排泄率（FENa）<0.5%、0.5%至1.5%和>1.5%的组。比较各组的生长参数，并评估其与FENa水平的关联。
结果
本研究纳入了44名（27名男孩和17名女孩）CF儿童。研究人群的平均年龄为55.63（33.2）个月。在研究的CF患者中，90.9%的BMI的z评分在-2_+2（正常范围），72.7%的体重z评分在正常范围，70%的身高z评分在正常范围。在CF儿童中，18名（40.9%）的FENa低于0.5，17名（38.6%）的FENA在0.5-1.5之间，9名的FENa>1.5。在研究的CF患者中，16名（88.9%）的血清钠水平正常，但FENa≤0.5。基于Spearman相关性检验，FENa分类与体重z评分（P=0.92）、身高z评分（P=0.83）和BMI z评分（P=0.99）之间均无显著相关性。
结论
我们的研究结果表明，大多数FENa水平低的患者血清钠水平正常。我们未发现FENa与生长参数之间存在显著关联。对于BMI，这种关联有显著趋势。建议这可能是由于对研究人群进行了适当的随访。然而，建议纳入健康受试者进行更多研究以获得更准确的结果。
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