细胞衰老：结直肠癌有前途的治疗靶点。

Cellular senescence: a promising therapeutic target in colorectal cancer.

机构信息

International Medical Services (IMS), Beijing Tiantan Hospital of Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.

Department of Pathology, Beijing Tiantan Hospital of Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.

出版信息

Future Oncol. 2022 Sep;18(30):3463-3470. doi: 10.2217/fon-2021-0661. Epub 2022 Sep 7.

DOI:10.2217/fon-2021-0661

PMID:36069254

Abstract

Colorectal cancer is one of the most malignant cancers worldwide, and efforts have been made to elucidate the mechanism of colorectal carcinogenesis. Cellular senescence is a physiological process in cell life, but it is also found in cancer initiation and progression. Lines of evidence show that senescence may influence the development and progression of colorectal carcinogenesis. Here, the authors review the characteristics of senescence and the recent findings of a relationship between senescence and colorectal cancer.

摘要

结直肠癌是全球最恶性的癌症之一，人们一直在努力阐明结直肠癌发生的机制。细胞衰老（senescence）是细胞生命过程中的一种生理现象，但它也存在于癌症的起始和进展中。有证据表明，衰老可能影响结直肠癌发生和进展。在这里，作者综述了衰老的特征以及衰老与结直肠癌之间关系的最新发现。