肠道微生物组与内耳轴的研究进展

Recent Advancements in Understanding the Gut Microbiome and the Inner Ear Axis.

机构信息

Department of Otolaryngology, Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine, Miami, FL, USA.

Department of Otolaryngology, Hearing Research and Cochlear Implant Laboratory, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA; Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

出版信息

Otolaryngol Clin North Am. 2022 Oct;55(5):1125-1137. doi: 10.1016/j.otc.2022.07.002. Epub 2022 Sep 7.

DOI:10.1016/j.otc.2022.07.002

PMID:36088154

Abstract

The gut microbiome and its dynamic association with organ systems beyond the gastrointestinal tract, such as the nervous and cardiovascular systems, is an emerging area of research. Although the role of the gut microbiome has been extensively characterized in the gut-brain axis, the implications of gut dysbiosis in inner ear inflammation and hearing deficits have still not been explored. With some similarities outlined between the blood-brain barrier (BBB) and the blood labyrinth barrier (BLB) of the inner ear, this review aims to explore the axis between the gut microbiome and the inner ear as it pertains to their bidirectional communication.

摘要

肠道微生物组及其与胃肠道以外的器官系统（如神经系统和心血管系统）的动态关联是一个新兴的研究领域。尽管肠道微生物组在肠道-大脑轴中的作用已经得到了广泛的描述，但肠道失调在内耳炎症和听力缺陷中的影响仍未得到探索。由于内耳的血脑屏障（BBB）和血迷路屏障（BLB）之间存在一些相似之处，本综述旨在探讨肠道微生物组与内耳之间的关联，以及它们之间的双向通讯。