促进或缓解：非编码 RNA 在结直肠癌抗 EGFR 治疗中的作用。
Promotion or remission: a role of noncoding RNAs in colorectal cancer resistance to anti-EGFR therapy.
机构信息
Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, Jiangsu, China.
Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China.
出版信息
Cell Commun Signal. 2022 Sep 21;20(1):150. doi: 10.1186/s12964-022-00960-x.
Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) patients. However, the generation of primary and secondary resistance to anti-EGFR mAbs has become an important factor restricting its efficacy. Recent studies have revealed that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are implicated in anti-EGFR antibodies resistance, affecting the sensitivity of CRC cells to Cetuximab and Panitumumab. This paper briefly reviewed the research advance of the expression, signaling network and functional mechanism of ncRNAs related to anti-EGFR mAbs resistance in CRC, as well as their relationship with clinical prognosis and the possibility of therapeutic targets. In addition, some ncRNAs that are involved in the regulation of signaling pathways or genes related to anti-EGFR resistance, but need to be further verified by resistance experiments were also included in this review, thereby providing more ideas and basis for ncRNAs as CRC prognostic markers and anti-EGFR therapy sensitizers. Video Abstract.
抗表皮生长因子受体（EGFR）单克隆抗体（mAbs）对 RAS 和 BRAF 野生型转移性结直肠癌（mCRC）患者具有重要意义。然而，抗 EGFR mAbs 产生原发性和继发性耐药已成为限制其疗效的重要因素。最近的研究表明，非编码 RNA（ncRNAs），特别是长非编码 RNA（lncRNAs）、微小 RNA（miRNAs）和环状 RNA（circRNAs），与抗 EGFR 抗体耐药性有关，影响 CRC 细胞对西妥昔单抗和帕尼单抗的敏感性。本文简要综述了 ncRNAs 与 CRC 抗 EGFR mAbs 耐药性相关的表达、信号网络和功能机制的研究进展，及其与临床预后的关系和作为治疗靶点的可能性。此外，本文还纳入了一些 ncRNAs，它们参与调节与抗 EGFR 耐药相关的信号通路或基因，但需要通过耐药实验进一步验证，从而为 ncRNAs 作为 CRC 预后标志物和抗 EGFR 治疗增敏剂提供更多的思路和依据。视频摘要。
Zotero 插件