Is a Novel Prognostic-Related Biomarker in Glioma Correlating with Immune Infiltrates and Response to Oxidative Stress by Temozolomide.

BACKGROUND

Gliomas are one of the most prevalent malignant brain tumors. Hence, identifying biological markers for glioma is imperative. (Tetratricopeptide Repeat Domain 7B) is a gene whose role in cancer in currently identified. To this end, we examined the expression as well as its prognostic significance, biological roles, and immune system impacts in patients with glioma.

METHODS

We evaluated the function of in GBM and LGG through the published CGGA (Chinese Glioma Genome Atlas) and TCGA (The Cancer Genome Atlas) databases. CIBERSORT and TIMER were used to analyze the link between and immune cells, while R was used for statistical analysis. In addition, Transwell analysis, including migration and invasion assays, was performed to identify the relationship between and temozolomide.

RESULTS

Low expression of was observed in GBM and LGG. 1p/19q codeletion, mutation, chemotherapy, and grade were found to have a significant correlation with . Besides, low expression was linked with low overall survival (OS) in both GBM and LGG. In the Cox analysis, was found to independently function as a risk element for OS of patients with glioma. Furthermore, CIBERSORT analysis demonstrated a positive link between and multiple immune cells, especially activated NK cells. Transwell analysis, including migration and invasion assays, revealed that temozolomide reduced the migration and invasion capacity of glioma cells and increased the expression of .

CONCLUSION

In all, could serve as a promising prognostic indicator of LGG and GBM, and is closely associated with immune infiltration and response to oxidative stress by temozolomide.