Lombarte Espinosa Evelyn, Villuendas Usón María Cruz, Arribas García Jorge, Jado García Isabel, Huarte Lacunza Rafael, Zárate Chug Paola, Claraco Vega Luis Manuel, Jesús Santed Andrés María, Ríos María Jiménez, Cook Rachel, Simard J Marc, Boyer Anne E, Rezusta Antonio
Servicio Medicina Intensiva, UCI Polivalente, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Servicio Microbiología, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, Spain.
Clin Infect Dis. 2022 Oct 17;75(Suppl 3):S364-S372. doi: 10.1093/cid/ciac531.
This report describes a 49-year-old male construction worker who acquired a Bacillus anthracis infection after working on a sheep farm. He experienced a severe respiratory infection, septic shock, and hemorrhagic meningoencephalitis with severe intracranial hypertension. After several weeks with multiple organ dysfunction syndrome, he responded favorably to antibiotic treatment. Three weeks into his hospitalization, an intracranial hemorrhage and cerebral edema led to an abrupt deterioration in his neurological status. A single dose of raxibacumab was added to his antimicrobial regimen on hospital day 27. His overall status, both clinical and radiographic, improved within a few days. He was discharged 2 months after admission and appears to have fully recovered.
本报告描述了一名49岁的男性建筑工人,他在一家养羊场工作后感染了炭疽芽孢杆菌。他经历了严重的呼吸道感染、感染性休克和出血性脑膜脑炎,并伴有严重的颅内高压。在出现多器官功能障碍综合征数周后,他对抗生素治疗反应良好。住院三周后,颅内出血和脑水肿导致他的神经状态突然恶化。在住院第27天,他的抗菌治疗方案中加用了单剂量的raxibacumab。几天后,他的临床和影像学总体状况均有所改善。入院2个月后他出院,似乎已完全康复。