通过环二鸟苷酸信号控制生物膜的形成。
Controlling Biofilm Development Through Cyclic di-GMP Signaling.
机构信息
Department of Biological Sciences, Binghamton University, Binghamton, NY, USA.
Binghamton Biofilm Research Center (BBRC), Binghamton University, Binghamton, NY, USA.
出版信息
Adv Exp Med Biol. 2022;1386:69-94. doi: 10.1007/978-3-031-08491-1_3.
Abstract
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date summary of c-di-GMP pathways connected to biofilm formation by the opportunistic pathogen P. aeruginosa. Emphasis will be on the timing of c-di-GMP production over the course of biofilm formation, to highlight non-uniform and hierarchical increases in c-di-GMP levels, as well as biofilm growth conditions that do not conform with our current model of c-di-GMP.
摘要
环二鸟苷酸（c-di-GMP）作为第二信使，调控着许多细菌行为，是驱动游动孤菌细胞和生物膜形成菌生活方式转换的关键。本综述概述了铜绿假单胞菌中与生物膜形成相关的 c-di-GMP 途径，重点介绍了 c-di-GMP 在生物膜形成过程中的产生时间，以突出 c-di-GMP 水平的非均匀和分层增加，以及不符合我们当前 c-di-GMP 模型的生物膜生长条件。
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