MMP8/MMP10 多态性在缺血性脑卒中易感性中的作用。

The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility.

机构信息

Department of Neurology, Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.

The College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.

出版信息

Brain Behav. 2022 Dec;12(12):e2797. doi: 10.1002/brb3.2797. Epub 2022 Oct 25.

DOI:10.1002/brb3.2797

PMID:36282475

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9759140/

Abstract

BACKGROUND

Ischemic stroke (IS), a multifactorial and polygenic disease, is the most common cause of death. This study aimed to determine the roles of MMP8/MMP10 polymorphisms in IS susceptibility in the Chinese Han population.

METHODS

MMP8 rs1940475 and rs3765620, and MMP10 rs17860949 from 700 IS patients and 700 controls were genotyped by the MassARRAY iPLEX platform. The impact of polymorphisms on IS risk was evaluated by logistic regression analysis.

RESULTS

Our study indicated that rs17860949 in MMP10 was significantly associated with a reduced risk of IS (OR = 0.632, p = .002). Precisely, stratification analysis showed that rs17860949 was relate to a decreased susceptibility to IS in patients aged > 55 years (OR = 0.472, p < .001), males (OR = 0.632, p = .012), nonsmokers (OR = 0.610, p = .017), and nondrinkers (OR = 0.559, p = .006). All these significant findings were verified by false-positive report probability test. Furthermore, GG genotype and AG genotype in MMP8 rs3765620 polymorphism were related to a reduced triglycerides concentration (p = .018).

CONCLUSION

Our study suggests that rs17860949 in MMP10 may play a protective role in IS in the Chinese Han population.

摘要

背景

缺血性脑卒中（IS）是一种多因素、多基因疾病，是最常见的死亡原因。本研究旨在确定 MMP8/MMP10 多态性在汉族人群中易患 IS 的作用。

方法

采用 MassARRAY iPLEX 平台对 700 例 IS 患者和 700 例对照的 MMP8 rs1940475 和 rs3765620 以及 MMP10 rs17860949 进行基因分型。通过逻辑回归分析评估多态性对 IS 风险的影响。

结果

本研究表明 MMP10 中的 rs17860949 与 IS 风险降低显著相关（OR=0.632，p=0.002）。具体而言，分层分析表明 rs17860949 与年龄>55 岁（OR=0.472，p<0.001）、男性（OR=0.632，p=0.012）、不吸烟者（OR=0.610，p=0.017）和不饮酒者（OR=0.559，p=0.006）的 IS 易感性降低相关。所有这些显著发现均通过假阳性报告概率检验得到验证。此外，MMP8 rs3765620 多态性中的 GG 基因型和 AG 基因型与甘油三酯浓度降低相关（p=0.018）。