用于神经系统再生与修复的细胞重编程
Cell Reprogramming for Regeneration and Repair of the Nervous System.
作者信息
Clark Isaac H, Roman Alex, Fellows Emily, Radha Swathi, Var Susanna R, Roushdy Zachary, Borer Samuel M, Johnson Samantha, Chen Olivia, Borgida Jacob S, Steevens Aleta, Shetty Anala, Strell Phoebe, Low Walter C, Grande Andrew W
机构信息
Department of Biomedical Engineering, Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Biomedicines. 2022 Oct 17;10(10):2598. doi: 10.3390/biomedicines10102598.
A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.
中枢神经系统和周围神经系统进行神经再生和修复的能力有限，这一直是神经疾病治愈和治疗的一个障碍。最近，人们开始通过对天然细胞进行细胞重编程来实现各种细胞类型的再生，这是一种很有前景的治疗方法，可以补充各种神经疾病中丢失或减少的细胞群体。本文综述深入分析了目前已研究的病毒载体、感兴趣的基因和靶细胞群体，以及这些新型疗法面临的挑战和未来方向。此外，还将讨论如何优化细胞重编程作为神经疾病治疗方法的机制，以及对最近体外和体内细胞重编程研究的综述。
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