职业消防员心血管代谢疾病的风险因素
Risk Factors for Cardiometabolic Disease in Professional Firefighters.
作者信息
McAllister Matthew J, Gonzalez Drew E, Leonard Megan, Martaindale M Hunter, Bloomer Richard J, Pence Jacquelyn, Martin Steven E
机构信息
From the Metabolic & Applied Physiology Laboratory, Department of Health & Human Performance, Texas State University, San Marcos, Texas (Dr McAllister); Department of Kinesiology and Sport Management, Texas A&M University, College Station, Texas (Mr Gonzalez, Ms Leonard, Dr Martin); ALERRT Center, Texas State University, San Marcos, Texas (Dr Martaindale); Cardiorespiratory/Metabolic Laboratory, Department of Health and Sport Sciences, Memphis, Tennessee (Dr Bloomer, Dr Pence).
出版信息
J Occup Environ Med. 2023 Feb 1;65(2):119-124. doi: 10.1097/JOM.0000000000002743. Epub 2022 Oct 31.
OBJECTIVE
Firefighters are plagued with cardiometabolic disease (CMD). Obesity, poor cardiorespiratory and muscular fitness, and blood lipids (low-density lipoprotein cholesterol, triglycerides, low high-density lipoprotein cholesterol) are risk factors for CMD. However, markers of oxidative stress, inflammation, and insulin resistance can provide further insight regarding CMD risk.
METHODS
This study investigated the relationships between fitness metrics (cardiorespiratory and muscular fitness, percent body fat, waist circumference), blood lipids, blood pressure, and years of experience as a firefighter to blood markers of insulin resistance: Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), oxidative stress: advanced oxidation protein products (AOPPs), and inflammation: C-reactive protein.
RESULTS
Waist circumference and blood concentrations of triglycerides were significantly related to AOPPs and HOMA-IR. Cardiorespiratory fitness was inversely related to AOPPs, HOMA-IR and C-reactive protein.
CONCLUSION
These findings demonstrate the importance of high cardiorespiratory fitness and low waist circumference to reduce markers of CMD.
目的
消防员饱受心脏代谢疾病（CMD）的困扰。肥胖、心肺功能和肌肉健康状况不佳以及血脂（低密度脂蛋白胆固醇、甘油三酯、低高密度脂蛋白胆固醇）是CMD的危险因素。然而，氧化应激、炎症和胰岛素抵抗的标志物可以为CMD风险提供进一步的见解。
方法
本研究调查了体能指标（心肺功能和肌肉健康状况、体脂百分比、腰围）、血脂、血压以及消防员工作年限与胰岛素抵抗血液标志物：胰岛素抵抗稳态模型评估（HOMA-IR）、氧化应激：晚期氧化蛋白产物（AOPPs）和炎症：C反应蛋白之间的关系。
结果
腰围和甘油三酯血液浓度与AOPPs和HOMA-IR显著相关。心肺功能与AOPPs、HOMA-IR和C反应蛋白呈负相关。
结论
这些发现表明高心肺功能和低腰围对于降低CMD标志物的重要性。
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