一种用于生物相关阳离子的水溶性膜转运蛋白。
A water-soluble membrane transporter for biologically relevant cations.
作者信息
Yang Kylie, Boles Jessica E, White Lisa J, Hilton Kira L F, Lai Hin Yuk, Long Yifan, Hiscock Jennifer R, Haynes Cally J E
机构信息
Chemistry Department, UCL 20 Gordon Street London WC1H 0AJ UK
School of Chemistry and Forensic Science, University of Kent Canterbury Kent CT2 7NH UK
出版信息
RSC Adv. 2022 Sep 29;12(43):27877-27880. doi: 10.1039/d2ra05314d. eCollection 2022 Sep 28.
Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.
合成离子载体是很有前景的治疗靶点，但水溶性差限制了它们转化为临床应用的潜力。在此，我们报告了一种水溶性超分子自缔合两亲物，它在合成囊泡系统中作为阳离子单向转运体发挥作用，并通过平面双层膜片钳实验获得了机制上的见解。
Zotero 插件