间充质干细胞在肿瘤治疗中的应用。
Application of mesenchymal stem cells in tumor therapy.
机构信息
Genetics Laboratory, College of Life Science, Central South University, Changsha 410078.
Hunan Key Laboratory of Medical Genetics, Changsha 410078.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Oct 28;47(10):1444-1453. doi: 10.11817/j.issn.1672-7347.2022.220116.
Mesenchymal stem cells (MSCs) are multipotent stem cells that exist widely in the human body, which can self-renewal and differentiate into different types of cell. Due to its advantages of tumor tissue tropism and easy to be engineered, it has been widely used in cancer treatment research recently. However, the tumor-promoting or anti-tumor effect of MSCs is controversial, especially for unmodified MSCs. Therefore, researchers are more inclined to use MSCs as carriers to engineer them. With the deepening in understanding of vesicles, it is found that the vesicles derived from MSCs seem to have greater advantages as carriers. Although the current research of MSCs in the treatment of tumors has been initiated in the clinic, there are still many problems to be solved in the pre-clinical application.
间充质干细胞（MSCs）是一种广泛存在于人体中的多能干细胞，具有自我更新和分化为不同类型细胞的能力。由于其对肿瘤组织的趋化性和易于工程化的优点，最近在癌症治疗研究中得到了广泛应用。然而，MSCs 的促肿瘤或抗肿瘤作用存在争议，特别是对于未经修饰的 MSCs 更是如此。因此，研究人员更倾向于使用 MSCs 作为载体来对其进行工程化改造。随着对囊泡的深入了解，发现来源于 MSCs 的囊泡作为载体似乎具有更大的优势。尽管 MSCs 在肿瘤治疗中的临床研究已经启动，但在临床前应用中仍有许多问题需要解决。
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