单核细胞/高密度脂蛋白胆固醇比值是频发室性期前收缩的危险因素：一项回顾性队列研究。
The monocyte to high-density lipoprotein cholesterol ratio is a risk factor for frequent premature ventricular complexes: a retrospective cohort study.
机构信息
Department of Cardiology, HHCH, Hefei, Anhui, China.
Department of Cardiology, FAHAMU, Hefei, Anhui, China.
出版信息
Lipids Health Dis. 2022 Dec 3;21(1):129. doi: 10.1186/s12944-022-01742-7.
BACKGROUND
Little is known about the link between the monocyte to high-density lipoprotein cholesterol ratio (MHR) and frequent premature ventricular complexes (PVCs). This investigation aimed to evaluate the link between the MHR and frequent PVCs in patients, as well as their outcomes, using the axis, burden, coupling interval-ventricular tachycardia (ABC-VT) risk score (ARS).
METHODS
Two hundred patients with frequent PVCs and 70 controls were retrospectively enrolled, and their general data were gathered. The MHR and ARS were calculated. Then, patients developing frequent PVCs were classified into a medium-/high-risk subgroup and a low-risk subgroup according to ARS. The results were evaluated employing comparative statistical analyses, Spearman's correlation, logistic regression analyses, and receiver operating characteristic (ROC) curves.
RESULTS
The MHR in the controls was obviously lower than that in the frequent PVC group. In addition, the MHR was the lowest in the control group and highest in the medium-/high-risk subgroup, with that of the low-risk subgroup falling in the middle. Spearman's correlation analyses showed that the MHR was positively correlated with the ARS (ρ = 0.307, P < 0.001). Ultimately, the MHR was found to be a risk factor for frequent PVCs in the multivariate analysis. In addition, an MHR cutoff point of 254.6 featured 67.50% sensitivity and 67.14% specificity for predicting frequent PVCs, and the area under the curve (AUC) reached 0.694 (95% confidence interval: 0.623-0.766) (P < 0.001).
CONCLUSIONS
The MHR is positively and independently correlated with frequent PVCs and can be used as a practical, cost-saving and simple biomarker of inflammation owing to its value in predicting frequent PVCs. In addition, the MHR is crucial to risk stratification and prognosis, which may give it clinical value in the prevention and management of frequent PVCs.
背景
单核细胞与高密度脂蛋白胆固醇比值（MHR）与频发室性早搏（PVCs）之间的关系知之甚少。本研究旨在使用轴、负荷、偶联间期-室性心动过速（ABC-VT）风险评分（ARS）评估 MHR 与频发 PVCs 患者及其结局之间的关系。
方法
回顾性纳入 200 例频发 PVCs 患者和 70 例对照者，收集其一般资料。计算 MHR 和 ARS。然后，根据 ARS 将频发 PVCs 患者分为中/高危亚组和低危亚组。采用比较统计学分析、Spearman 相关性分析、Logistic 回归分析和受试者工作特征（ROC）曲线评估结果。
结果
对照组的 MHR 明显低于频发 PVC 组。此外，MHR 在对照组中最低，在中/高危亚组中最高，在低危亚组中居中。Spearman 相关性分析显示，MHR 与 ARS 呈正相关（ρ=0.307，P<0.001）。最终，多变量分析显示 MHR 是频发 PVCs 的危险因素。此外，MHR 截断点为 254.6 时，预测频发 PVCs 的敏感性为 67.50%，特异性为 67.14%，曲线下面积（AUC）为 0.694（95%置信区间：0.623-0.766）（P<0.001）。
结论
MHR 与频发 PVCs 呈正相关且独立相关，可作为一种实用、节省成本和简单的炎症标志物，因其对预测频发 PVCs 具有价值。此外，MHR 对危险分层和预后至关重要，这可能使其在预防和管理频发 PVCs 方面具有临床价值。
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