用于睡眠呼吸障碍的正压通气设备中消声材料的潜在健康风险：迄今研究综述
Potential health risks of sound abatement material in positive airway pressure devices for sleep breathing disorders: a summary of studies to date.
作者信息
Wang Yuxin, Xiao Yi
机构信息
Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
出版信息
Sleep Breath. 2023 Oct;27(5):1925-1927. doi: 10.1007/s11325-022-02763-3. Epub 2022 Dec 15.
PURPOSE
The potential carcinogenic and airway irritation risks of polyester-based polyurethane (PE-PUR) contained in sound-absorbing foam in positive airway pressure (PAP) devices have raised many concerns. We summarize the currently available studies to assess the potential health risks of PE-PUR.
METHODS
We searched Pubmed and Web of Science for studies on the safety of PAP devices containing PE-PUF and performed a systematic analysis of the cancer risk.
RESULTS
PE-PUR did not increase the cancer risk (OR: 1.08, 95% CI: 0.99-1.17, I2 = 0%). Patients in the group of PE-PUR devices had increased airway irritation, and they had higher rates of using short-acting beta-agonists and oral corticosteroids (SABA: 9.4% vs. 8.8%, p = 0.047; OCS: 19.7% vs. 17.3%, p < 0.001).
CONCLUSION
The application of PE-PUF can increase airway irritation, but there is no evidence for its potential carcinogenicity.
目的
正压通气（PAP）设备中吸音泡沫所含的聚酯基聚氨酯（PE-PUR）存在潜在致癌和气道刺激风险，引发了诸多担忧。我们总结当前可得研究，以评估PE-PUR的潜在健康风险。
方法
我们在PubMed和科学网搜索了关于含PE-PUF的PAP设备安全性的研究，并对癌症风险进行了系统分析。
结果
PE-PUR未增加癌症风险（比值比：1.08，95%置信区间：0.99 - 1.17，I² = 0%）。使用PE-PUR设备的患者气道刺激增加，且使用短效β-激动剂和口服糖皮质激素的比例更高（短效β-激动剂：9.4%对8.8%，p = 0.047；口服糖皮质激素：19.7%对17.3%，p < 0.001）。
结论
PE-PUF的应用会增加气道刺激，但尚无证据表明其具有潜在致癌性。
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