饮茶与肾结石风险：一项基于孟德尔随机化的研究。

Tea intake and risk of kidney stones: A mendelian randomization study.

机构信息

Department of Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Department of Geriatrics, The Third Affiliated Hospital of Soochow University, Changzhou, China.

出版信息

Nutrition. 2023 Mar;107:111919. doi: 10.1016/j.nut.2022.111919. Epub 2022 Nov 25.

DOI:10.1016/j.nut.2022.111919

PMID:36542873

Abstract

OBJECTIVES

Observational studies indicate that tea intake is associated with a decreased risk of kidney stones. Here we performed a mendelian randomization (MR) analysis to evaluate whether this association is causal.

METHODS

Forty-four independent genetic variants strongly associated with tea intake were identified from a large genome-wide association study, including 448 060 individuals of the UK Biobank. We additionally obtained genome-wide association study summary statistics for kidney stones from the FinnGen consortium (5985 cases and 253 943 controls) and UK Biobank (6536 cases and 388 508 controls). Random-effect inverse variance weighted regression was used to evaluate causal estimates. The random-effect inverse variance weighted estimates based on the FinnGen consortium and UK Biobank were meta-analyzed using fixed-effects meta-analysis. Other MR methods, including MR-Egger, weighted median, weighted mode, and MR-Pleiotropy RESidual Sum and Outlier, were also performed to test the robustness of our results.

RESULTS

In a combined sample of 12 521 cases and 642 451 controls, the inverse variance weighted analysis indicated that genetically predicted tea intake was causally associated with a decreased risk of kidney stones (odds ratio = 0.47; 95% CI, 0.34-0.66; P < 0.001). This association was consistent in other MR methods.

CONCLUSIONS

This study suggests that tea intake may be causally associated with a decreased risk of kidney stones.

摘要

目的

观察性研究表明，饮茶与肾结石风险降低有关。本研究采用孟德尔随机化（MR）分析来评估这种关联是否具有因果关系。

方法

从英国生物库的 448060 名个体中，确定了与饮茶强烈相关的 44 个独立的遗传变异，包括 448060 名个体。我们还从芬兰基因联合会（5985 例病例和 253943 例对照）和英国生物库（6536 例病例和 388508 例对照）获得了肾结石的全基因组关联研究汇总统计数据。采用随机效应逆方差加权回归评估因果估计值。基于芬兰基因联合会和英国生物库的随机效应逆方差加权估计值使用固定效应荟萃分析进行荟萃分析。还使用了其他 MR 方法，包括 MR-Egger、加权中位数、加权众数和 MR-Pleiotropy RESidual Sum and Outlier，以检验结果的稳健性。