Günes Ömer, Gülhan Belgin, Guney Ahmet Yasin, Üçkardeş Fatih, Ozen Seval, Guder Latife, Mustafaoglu Ozlem, Bayraktar Pinar, Yahşi Aysun, Erat Tuğba, Kanik-Yuksek Saliha, Bayhan Gulsum Iclal, Ozkaya-Parlakay Aslınur
Department of Pediatric Infectious Diseases, Ankara City Hospital, 06800 Ankara, Turkey.
Department of Biostatistics and Medical Informatics, Faculty of Medicine, Adıyaman University, Adıyaman 02040, Turkey.
J Trop Pediatr. 2022 Dec 5;69(1). doi: 10.1093/tropej/fmac105.
This study aimed to determine whether parental vaccination against coronavirus disease 2019 (COVID-19) prevents hospitalization of COVID-19-infected children.
This study was based on data obtained from the records of pediatric patients that were followed up for virologically proven COVID-19 infection between August and October 2021, during which time the delta variant was dominant in Turkey and the children were isolating at home.
There were 151 patients in the inpatient group and 218 in the outpatient group; the mean age was 172.5 and 145.5 months in the groups, respectively. The rates of obesity (22.5% and 6.4%, respectively, p < 0.001) and neurological-neurodevelopmental disorders (8.6% and 1.4%, respectively, p < 0.001) were significantly higher in the inpatient group than in the outpatient group. Of the outpatients' parents, 67.4% (n = 147) were fully vaccinated vs. 38.4% (n = 58) in the inpatient group. In all, 39.7% (n = 60) of the inpatients' parents were unvaccinated vs. 18.3% (n = 40) in the outpatient group. There was a significant correlation between the vaccination status and the patient groups (p < 0.001); it was determined that the COVID-19 infection would be mild in children if both parents were fully vaccinated. When both parents were fully vaccinated against COVID-19, the hospitalization rate decreased and the outpatient follow-up rate increased.
Having both parents fully vaccinated against COVID-19 can indirectly protect their subsequently infected children from hospitalization and the long-term effects of infection. Nonetheless, more comprehensive research on delta and non-delta variants is needed.
本研究旨在确定父母接种2019冠状病毒病(COVID-19)疫苗是否能预防COVID-19感染儿童住院。
本研究基于2021年8月至10月期间对经病毒学证实为COVID-19感染的儿科患者记录所获得的数据,在此期间,德尔塔变异株在土耳其占主导地位,且儿童居家隔离。
住院组有151例患者,门诊组有218例患者;两组的平均年龄分别为172.5个月和145.5个月。住院组的肥胖率(分别为22.5%和6.4%,p<0.001)和神经-神经发育障碍率(分别为8.6%和1.4%,p<0.001)显著高于门诊组。门诊患者的父母中,67.4%(n=147)已完全接种疫苗,而住院组为38.4%(n=58)。总体而言,住院患者的父母中有39.7%(n=60)未接种疫苗,门诊组为18.3%(n=40)。疫苗接种状况与患者组之间存在显著相关性(p<0.001);已确定如果父母双方均已完全接种疫苗,儿童的COVID-19感染将较为轻微。当父母双方均已完全接种COVID-19疫苗时,住院率降低,门诊随访率增加。
父母双方均已完全接种COVID-19疫苗可间接保护其随后感染的儿童免予住院及感染的长期影响。尽管如此,仍需要对德尔塔和非德尔塔变异株进行更全面的研究。