线粒体稳态和动态平衡与胃肠癌恶性生物学行为的关系。
Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer.
机构信息
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China.
出版信息
J Transl Med. 2023 Jan 16;21(1):27. doi: 10.1186/s12967-023-03878-1.
Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitochondrial dynamics has been found to influence the biological behaviors of gastrointestinal cancer with the potential to be a novel target for its individualized therapy. This review systematically introduced the role of mitochondrial dynamics in maintaining mitochondrial homeostasis, and further elaborated the effects of disrupted mitochondrial dynamics on the cellular biological behaviors of gastrointestinal cancer as well as its association with cancer progression. We aim to provide clues for elucidating the etiology and pathogenesis of gastrointestinal cancer from the perspective of mitochondrial homeostasis and disorder.
线粒体决定了大多数真核生物的生理状态。线粒体动力学在维持线粒体稳态中起着重要作用，而线粒体动力学的紊乱会影响细胞能量代谢，导致肿瘤发生。近年来，研究发现，破坏线粒体动力学会影响胃肠道癌的生物学行为，有可能成为其个体化治疗的新靶点。本文系统介绍了线粒体动力学在维持线粒体稳态中的作用，进一步阐述了破坏线粒体动力学对胃肠道癌细胞生物学行为的影响及其与癌症进展的关系。我们旨在从线粒体稳态和紊乱的角度为阐明胃肠道癌的病因和发病机制提供线索。
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