Tan Yujing, Su Jianhui, Fu Minghui, Zhang Hongmei, Zeng Haiyan
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Bioengineering (Basel). 2022 Dec 27;10(1):35. doi: 10.3390/bioengineering10010035.
is an important opportunistic pathogen common in clinical infections. Phage therapy become a hot research field worldwide again after the post-antibiotic era. This review summarizes the important progress of phage treatments for in the last five years, and focus on the new interesting advances including the combination of phage and other substances (like photosensitizer), and the phage encapsulation (by microparticle, hydrogel) in delivery. We also discuss the remaining challenges and promising directions for phage-based therapy of infection in the future, and the innovative combination of materials in this area may be one promising direction.
是临床感染中常见的重要机会致病菌。在抗生素后时代,噬菌体疗法再次成为全球热门的研究领域。本综述总结了过去五年噬菌体治疗的重要进展,并重点关注了新的有趣进展,包括噬菌体与其他物质(如光敏剂)的联合使用,以及在递送过程中通过微粒、水凝胶对噬菌体进行封装。我们还讨论了未来基于噬菌体治疗感染所面临的挑战和有前景的方向,该领域材料的创新组合可能是一个有前景的方向。