胡椒科植物精油对刚地弓形虫速殖子的体外活性
In Vitro Activity of Essential Oils from Species (Piperaceae) against Tachyzoites of .
作者信息
Pereira Filho Adalberto Alves, Cunha Mariana Maciel, Alves Stanton Mariana, Fumiko Yamaguchi Lydia, Jorge Kato Massuo, Martins-Duarte Érica S
机构信息
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil.
Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, São Paulo, Brazil.
出版信息
Metabolites. 2023 Jan 6;13(1):95. doi: 10.3390/metabo13010095.
Toxoplasmosis is a tropical and neglected disease caused by the parasitic protozoa . Conventional treatment with sulfadiazine and pyrimethamine plus folinic acid, has some drawbacks, such as inefficacy in the chronic phase, toxic side effects, and potential cases of resistance have been observed. In this study, the activity of essential oils (EOs) from three species and their main constituents, including α-Pinene ( and ), β-Pinene (), and dillapiole (), were evaluated against tachyzoites of . α-Pinene was more active [(IC 0.3265 (0.2958 to 0.3604) μg/mL)] against tachyzoites than EO [0.8387 (0.6492 to 1.084) μg/mL]. Both α-Pinene and EO exhibited low cytotoxicity against NHDF cells, with CC 41.37 (37.64 to 45.09) µg/mL and 83.80 (75.42 to 91.34) µg/mL, respectively, suggesting they could be of potential use against toxoplasmosis.
弓形虫病是一种由寄生原生动物引起的热带病和被忽视的疾病。使用磺胺嘧啶、乙胺嘧啶加亚叶酸的传统治疗方法存在一些缺点，如在慢性期无效、有毒副作用，并且已观察到潜在的耐药病例。在本研究中，评估了三种植物精油（EOs）及其主要成分（包括α-蒎烯（和）、β-蒎烯（）和莳萝脑（））对刚地弓形虫速殖子的活性。α-蒎烯对速殖子的活性[IC 0.3265（0.2958至0.3604）μg/mL]高于精油[0.8387（0.6492至1.084）μg/mL]。α-蒎烯和精油对人正常皮肤成纤维细胞（NHDF）的细胞毒性均较低，CC分别为41.37（37.64至45.09）µg/mL和83.80（75.42至91.34）µg/mL，表明它们可能对弓形虫病有潜在的治疗作用。
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