用于提高抗菌活性的HJH抗菌肽的合理设计。

Rational design of HJH antimicrobial peptides to improve antimicrobial activity.

作者信息

Wang Yiming, Zhu Guilan, Wang Wei, Zhang Yan, Zhu Yong, Wang Jingjing, Geng Ming, Lu Hongxia, Chen Yajun, Zhou Minghui, Chen Jing, Zhang Fangyan, Yang Junjie, Cheng Xiaozhong

机构信息

Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration, Hefei Normal University, Hefei 230601, China.

出版信息

Bioorg Med Chem Lett. 2023 Mar 1;83:129176. doi: 10.1016/j.bmcl.2023.129176. Epub 2023 Feb 8.

DOI:10.1016/j.bmcl.2023.129176

PMID:36764469

Abstract

Antimicrobial peptides (AMPs) have attracted considerable interest in the past decade due to their advantages for tackling antibiotic resistance. They exhibit potential antimicrobial activity through unique cell membrane destruction mechanism based on their net charge, hydrophobic properties, and α-helix. In this work, a series of HJH peptides was rationally designed and synthesized. The antimicrobial activity and cytotoxicity assays indicated that HJH-5 and HJH-6 containing hydrophobic residues and helices displayed prominent antimicrobial activity and mild cytotoxicity, respectively. These peptides may be developed for combatting microbial infections.

摘要

在过去十年中，抗菌肽（AMPs）因其在应对抗生素耐药性方面的优势而备受关注。它们基于净电荷、疏水特性和α-螺旋，通过独特的细胞膜破坏机制展现出潜在的抗菌活性。在这项工作中，我们合理设计并合成了一系列HJH肽。抗菌活性和细胞毒性测定表明，含有疏水残基和螺旋的HJH-5和HJH-6分别表现出显著的抗菌活性和轻微的细胞毒性。这些肽有望被开发用于对抗微生物感染。