经验性饮食炎症模式评分与护士健康研究中的认知表现恶化无关。
Empirical Dietary Inflammatory Pattern Scores Are Not Associated with Worse Cognitive Performance in the Nurses' Health Study.
机构信息
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; The Framingham Heart Study, Framingham, MA, USA.
Bordeaux Population Health Research Center, Inserm U1219, Bordeaux, France; University of Bordeaux, Bordeaux, France.
出版信息
J Nutr. 2022 Nov;152(11):2526-2533. doi: 10.1093/jn/nxac157. Epub 2022 Jul 26.
BACKGROUND
Low-grade chronic inflammation associated with unhealthy diets may lead to cognitive aging.
OBJECTIVES
We evaluated whether higher long-term adherence to an empirical dietary inflammatory pattern (EDIP) was associated with lower cognitive function after age 70 y in the Nurses' Health Study.
METHODS
A total of 16,058 older (mean ± SD age: 74 ± 2 y) highly educated (≥ bachelor degree) White women completed up to 5 validated 116-item food-frequency questionnaires. An EDIP score, previously derived with the use of reduced rank regression to predict circulating inflammatory markers (i.e., C-reactive protein, TNF-α receptor 2, and IL-6), was computed based on 9 anti-inflammatory and 9 proinflammatory components. A long-term EDIP score was calculated by averaging across 5 exams. The EDIP score was categorized into quintiles, taking the first (anti-inflammatory) quintile as the reference category. Cognitive testing was performed through telephone interviews over 4 follow-up exams (1995-2008). A composite global cognition score, a composite verbal memory score, and the Telephone Interview for Cognitive Status (TICS) were calculated and averaged across the 4 exams (6 y of follow-up). Multivariable linear regressions were used to examine longitudinal relations under study.
RESULTS
Higher long-term EDIP scores (i.e., more proinflammatory) were significantly associated with worse performance on global cognitive function (P-trend= 0.018) and TICS (P-trend= 0.004) after adjustment for demographic and lifestyle factors. The associations became nonsignificant after additional adjustments for disease (related) risk factors for dementia. No association was observed between the EDIP score and verbal memory.
CONCLUSIONS
We observed no relation between long-term EDIP scores and averaged global cognitive function and verbal memory among older women. Our findings suggest no relation between long-term adherence to a proinflammatory diet and cognitive function in a large population of mostly White and generally highly educated older women. Future studies are encouraged to investigate the relation between inflammatory diets and cognitive function in other races/ethnicities and men, and over a longer follow-up period.
背景
与不健康饮食相关的低度慢性炎症可能导致认知老化。
目的
我们评估了在护士健康研究中，长期遵循经验性饮食炎症模式（EDIP）是否与 70 岁以上的认知功能下降有关。
方法
共有 16058 名年龄较大（平均年龄 ± 标准差：74 ± 2 岁）、教育程度较高（≥学士学位）的白人女性完成了多达 5 份经过验证的 116 项食物频率问卷。根据 9 种抗炎和 9 种促炎成分，使用降秩回归来预测循环炎症标志物（即 C 反应蛋白、TNF-α受体 2 和 IL-6），计算出 EDIP 评分。通过 5 次考试的平均值计算长期 EDIP 评分。EDIP 评分分为五组，第一组（抗炎）为参考组。认知测试通过电话访谈在 4 次随访（1995-2008 年）中进行。计算并平均了 4 次考试的综合全球认知评分、综合言语记忆评分和电话访谈认知状态（TICS）。使用多变量线性回归来研究纵向关系。
结果
长期 EDIP 评分较高（即更促炎）与全球认知功能（趋势 P=0.018）和 TICS（趋势 P=0.004）的表现较差显著相关，在调整人口统计学和生活方式因素后。在进一步调整与痴呆相关的疾病危险因素后，这些关联变得无统计学意义。EDIP 评分与言语记忆之间没有关联。
结论
我们没有观察到长期 EDIP 评分与老年女性的平均全球认知功能和言语记忆之间存在关系。我们的研究结果表明，在大多数白人且教育程度普遍较高的老年女性中，长期遵循促炎饮食与认知功能之间没有关系。鼓励未来的研究在其他种族/族裔和男性中以及在更长的随访期间，研究炎症饮食与认知功能之间的关系。
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