lncRNA-XIST/miRNAs/mRNAs 在人类癌细胞中的潜在作用。
Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells.
机构信息
Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Clin Transl Oncol. 2023 Jul;25(7):2015-2042. doi: 10.1007/s12094-023-03110-y. Epub 2023 Feb 28.
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
长非编码 RNA（lncRNA）是一类含有 200 个核苷酸以上但不编码蛋白质的非编码 RNA。在肿瘤发生过程中，lncRNA 可以具有致癌和抑癌双重特性。X 失活特异性转录本（XIST）是一种已知的 lncRNA，它参与了女性细胞中 X 染色体的沉默。XIST 的失调与多种癌症的风险增加有关。因此，XIST 可以作为人类恶性肿瘤有预后价值的生物标志物。在这篇综述中，我们试图总结 XIST 在人类癌症中的作用。
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