核仁磷酸蛋白在修复 DNA 损伤中发挥作用，是癌症治疗的靶点。
Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment.
机构信息
Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.
出版信息
Cancer Res. 2023 May 15;83(10):1573-1580. doi: 10.1158/0008-5472.CAN-22-3631.
Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1 expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein involved in numerous cellular functions that include participating in liquid-liquid phase separation, ribosome biogenesis, chaperoning of histones, and modulation of transcription. In this review, we discuss the underappreciated role of NPM1 in DNA damage repair, specifically Polη-mediated translesion synthesis, base excision, and homologous recombination and highlight the therapeutic potential of NPM1 targeting in cancer treatment.
核仁磷酸蛋白（Nucleophosmin，NPM1）在急性髓系白血病中经常发生突变，并且在几种癌症类型中表达升高。NPM1 是一种多功能寡聚蛋白，参与多种细胞功能，包括参与液-液相分离、核糖体生物发生、组蛋白伴侣和转录调节。在这篇综述中，我们讨论了 NPM1 在 DNA 损伤修复中的作用，特别是 Polη 介导的跨损伤合成、碱基切除和同源重组，并强调了针对 NPM1 在癌症治疗中的治疗潜力。
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