单细胞分辨率的脂肪组织。
Adipose tissue at single-cell resolution.
机构信息
Center for Functional Genomics and Tissue Plasticity, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.
Department of Internal Medicine, Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, TX, USA.
出版信息
Cell Metab. 2023 Mar 7;35(3):386-413. doi: 10.1016/j.cmet.2023.02.002.
Abstract
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological conditions. The emergence of single-cell transcriptomics has rapidly transformed our understanding of the diverse array of cell types and cell states residing in adipose tissues and has provided insight into how transcriptional changes in individual cell types contribute to tissue plasticity. Here, we present a comprehensive overview of the cellular atlas of adipose tissues focusing on the biological insight gained from single-cell and single-nuclei transcriptomics of murine and human adipose tissues. We also offer our perspective on the exciting opportunities for mapping cellular transitions and crosstalk, which have been made possible by single-cell technologies.
摘要
脂肪组织表现出显著的可塑性，能够在生理和病理生理条件下改变大小和细胞组成。单细胞转录组学的出现迅速改变了我们对存在于脂肪组织中的各种细胞类型和细胞状态的理解，并深入了解了单个细胞类型的转录变化如何促进组织可塑性。在这里，我们全面概述了脂肪组织的细胞图谱，重点介绍了从小鼠和人类脂肪组织的单细胞和单核转录组学中获得的生物学见解。我们还对通过单细胞技术实现的细胞转变和串扰的映射提供了我们的看法。
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