Nie Lei, Wei Qianqian, Li Jingyu, Deng Yaling, He Xiaorui, Gao Xinyue, Ma Xiao, Liu Shuang, Sun Yanfang, Jiang Guohua, Okoro Oseweuba Valentine, Shavandi Amin, Jing Shengli
College of Life Sciences, Xinyang Normal University Xinyang 464000 China
Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt 50 - CP 165/61 1050 Brussels Belgium
RSC Adv. 2023 Mar 14;13(13):8502-8522. doi: 10.1039/d2ra07195a.
Conductive hydrogels are platforms recognized as constituting promising materials for tissue engineering applications. This is because such conductive hydrogels are characterized by the inherent conductivity properties while retaining favorable biocompatibility and mechanical properties. These conductive hydrogels can be particularly useful in enhancing wound healing since their favorable conductivity can promote the transport of essential ions for wound healing the imposition of a so-called transepithelial potential. Other valuable properties of these conductive hydrogels, such as wound monitoring, stimuli-response , are also discussed in this study. Crucially, the properties of conductive hydrogels, such as 3D printability and monitoring properties, suggest the possibility of its use as an alternative wound dressing to traditional dressings such as bandages. This review, therefore, seeks to comprehensively explore the functionality of conductive hydrogels in wound healing, types of conductive hydrogels and their preparation strategies and crucial properties of hydrogels. This review will also assess the limitations of conductive hydrogels and future perspectives, with an emphasis on the development trend for conductive hydrogel uses in wound dressing fabrication for subsequent clinical applications.
导电水凝胶是被公认为在组织工程应用中构成有前景材料的平台。这是因为此类导电水凝胶的特点是具有固有导电性能,同时保留良好的生物相容性和机械性能。这些导电水凝胶在促进伤口愈合方面可能特别有用,因为它们良好的导电性可以促进伤口愈合所需离子的运输,即施加所谓的跨上皮电位。本研究还讨论了这些导电水凝胶的其他有价值的特性,如伤口监测、刺激响应。至关重要的是,导电水凝胶的特性,如3D可打印性和监测特性,表明其有可能作为绷带等传统敷料的替代伤口敷料。因此,本综述旨在全面探索导电水凝胶在伤口愈合中的功能、导电水凝胶的类型及其制备策略以及水凝胶的关键特性。本综述还将评估导电水凝胶的局限性和未来前景,重点是导电水凝胶在伤口敷料制造中用于后续临床应用的发展趋势。