早期环境与端粒：一种长期的毒性关系。
Early Environment and Telomeres: a Long-Term Toxic Relationship.
机构信息
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168Th Street, Suite 1105E, New York, NY, 10032, USA.
Instituto Nacional de Cancerología - México, 14080, Mexico City, Mexico.
出版信息
Curr Environ Health Rep. 2023 Jun;10(2):112-124. doi: 10.1007/s40572-023-00395-7. Epub 2023 Mar 22.
PURPOSE OF REVIEW
Telomere length (TL) shortening is a hallmark of biological aging. While studies have extensively focused on the impact of environmental exposures on TL in older populations, consistent evidence indicates that prenatal environmental exposures to air pollutants, polycyclic aromatic hydrocarbons, metals, and endocrine-disrupting chemicals influence TL shortening. Here, we summarize evidence linking prenatal environmental exposures with children's TL and discuss potential long-term effects.
RECENT FINDINGS
Current evidence shows that prenatal environmental exposures alter TL and identify pregnancy as a critical window of susceptibility for telomere damage in children. However, results vary across studies, possibly depending on the source, exposure time window, and stage evaluated. Additional research is needed to investigate whether early TL alterations mediate long-term health effects of offspring. Prenatal environmental exposures induce early childhood changes in TL. Based on known links between TL and biological aging, these alterations may have long-term impact on individuals' health throughout life.
目的综述
端粒长度（TL）缩短是生物衰老的一个标志。虽然研究广泛关注环境暴露对老年人 TL 的影响，但一致的证据表明，产前环境暴露于空气污染物、多环芳烃、金属和内分泌干扰化学物质会导致 TL 缩短。在这里，我们总结了与产前环境暴露与儿童 TL 相关的证据，并讨论了潜在的长期影响。
最近的发现
目前的证据表明，产前环境暴露会改变 TL，并确定妊娠是儿童端粒损伤的一个关键易感窗口。然而，研究结果因研究而异，这可能取决于来源、暴露时间窗和评估阶段。需要进一步的研究来探讨早期 TL 改变是否介导后代的长期健康影响。产前环境暴露会导致儿童早期 TL 发生变化。基于 TL 与生物衰老之间的已知联系，这些变化可能会对个体一生的健康产生长期影响。
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