两种摩洛哥植物提取物对寻常痤疮的疗效：植物化学成分分析、抗氧化、抗炎和抗菌活性。
Efficacy of Two Moroccan Species Extracts against Acne Vulgaris: Phytochemical Profile, Antioxidant, Anti-Inflammatory and Antimicrobial Activities.
机构信息
Laboratory of Sustainable Development and Health Research (LRDDS), Faculty of Sciences and Technology, Cadi Ayyad University, 549 Bd Abdelkrim Al Khattabi, Marrakesh 40000, Morocco.
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.
出版信息
Molecules. 2023 Mar 20;28(6):2797. doi: 10.3390/molecules28062797.
BACKGROUND
The genus L. (Cistaceae) includes several medicinal plants growing wild in the Moroccan area. Acne vulgaris (AV) is a chronic skin disorder treated with topical and systemic therapies that often lead to several side effects in addition to the development of antimicrobial resistance. Our study aimed to investigate the bioactivity of extracts of two Moroccan species, L. and L., in view of their use as potential coadjuvants in the treatment of mild acne vulgaris.
METHODS
Targeted phytochemical profiles obtained by HPLC-DAD and HPLC-ESI/MS analyses and biological activities ascertained by several antioxidants in vitro chemical and cell-based assays of the leaf extracts. Moreover, antimicrobial activity against Gram-positive and Gram-negative bacteria, and was evaluated.
RESULTS
Analyses revealed the presence of several polyphenols in the studied extracts, mainly flavonoids and tannins. L. and L. possessed good biological properties and all extracts showed antibacterial activity, particularly against , and , identified as the main acne-causing bacteria.
CONCLUSION
The results suggest that examined extracts are promising agents worthy of further studies to develop coadjuvants/natural remedies for mild acne treatment.
背景
属（唇形科）包括几种在摩洛哥地区野生生长的药用植物。寻常痤疮（AV）是一种慢性皮肤病，采用局部和全身治疗，除了导致抗菌耐药性的发展外，还常常导致多种副作用。我们的研究旨在研究两种摩洛哥 种， 和 的提取物的生物活性，鉴于它们可用作轻度寻常痤疮治疗的潜在辅助剂。
方法
通过 HPLC-DAD 和 HPLC-ESI/MS 分析获得的靶向植物化学特征图谱，以及通过几种体外化学和基于细胞的抗氧化剂活性测定法确定的叶片提取物的生物活性。此外，还评估了对革兰氏阳性和革兰氏阴性细菌以及 的抗菌活性。
结果
分析表明，在所研究的提取物中存在几种多酚类物质，主要是类黄酮和单宁。 和 具有良好的生物学特性，所有提取物均表现出抗菌活性，特别是对 、 和 ，这些细菌被认为是引起痤疮的主要细菌。
结论
结果表明，检查过的提取物是有前途的药物，值得进一步研究，以开发用于轻度痤疮治疗的辅助剂/天然疗法。
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