胰腺癌：进展与挑战。
Pancreatic cancer: Advances and challenges.
机构信息
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA; Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA 92868, USA.
Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Cell. 2023 Apr 13;186(8):1729-1754. doi: 10.1016/j.cell.2023.02.014.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant efforts have largely defined major genetic factors driving PDAC pathogenesis and progression. Pancreatic tumors are characterized by a complex microenvironment that orchestrates metabolic alterations and supports a milieu of interactions among various cell types within this niche. In this review, we highlight the foundational studies that have driven our understanding of these processes. We further discuss the recent technological advances that continue to expand our understanding of PDAC complexity. We posit that the clinical translation of these research endeavors will enhance the currently dismal survival rate of this recalcitrant disease.
胰腺导管腺癌（PDAC）仍然是最致命的癌症之一。大量的努力主要定义了驱动 PDAC 发病机制和进展的主要遗传因素。胰腺肿瘤的特征是复杂的微环境，协调代谢改变，并支持在这个小生境中各种细胞类型之间相互作用的环境。在这篇综述中，我们强调了推动我们对这些过程的理解的基础研究。我们进一步讨论了不断扩展我们对 PDAC 复杂性的理解的最新技术进步。我们认为，这些研究工作的临床转化将提高这种难治性疾病目前令人沮丧的生存率。
Zotero 插件