Nrf2 通路的激活作为对抗氧化应激诱导疾病的保护机制：虾青素的潜力。
Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin.
机构信息
School of Natural Sciences, and ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW, 2109, Australia; Institute of Chemical Engineering, Ural Federal University Named After the First President of Russia B.N. Yeltsin, Mira Street 28, 620002, Ekaterinburg, Russia.
Institute of Chemical Engineering, Ural Federal University Named After the First President of Russia B.N. Yeltsin, Mira Street 28, 620002, Ekaterinburg, Russia.
出版信息
Arch Biochem Biophys. 2023 Jun;741:109601. doi: 10.1016/j.abb.2023.109601. Epub 2023 Apr 20.
Astaxanthin, a red-orange liposoluble carotenoid, has been the centre of considerable attention in recent years for its numerous biological activities, notably its potent antioxidant activity. It is reported that astaxanthin elicits these biological activities via a number of cellular pathways. The Nrf2/Keap1 pathway is a major regulator of the antioxidant defence system of cells; it modulates the expression of a plethora of genes related to redox homeostasis as well as cellular detoxification. The pathway has received lots of attention as a prospective therapeutic target for diseases related to oxidative stress and inflammation. Several reports have shown that the pathway is inducible by many natural compounds. This present work reviews the Nrf2/Keap1 pathway, its regulation and involvement in diseases, provides a brief overview of naturally occurring compounds as activators of the pathway as well as discusses the effect of astaxanthin on the pathway.
虾青素，一种红橙色脂溶性类胡萝卜素，近年来因其众多的生物活性而受到广泛关注，特别是其强大的抗氧化活性。据报道，虾青素通过多种细胞途径发挥这些生物活性。Nrf2/Keap1 途径是细胞抗氧化防御系统的主要调节剂；它调节与氧化还原稳态以及细胞解毒相关的大量基因的表达。该途径作为与氧化应激和炎症相关疾病的潜在治疗靶点受到了广泛关注。有几项报道表明，该途径可被许多天然化合物诱导。本研究综述了 Nrf2/Keap1 途径及其调控和在疾病中的作用，简要概述了作为该途径激活剂的天然存在的化合物，并讨论了虾青素对该途径的影响。
Zotero 插件