EZH2 可作为抑制血管内皮功能障碍的治疗药物。

EZH2 can be used as a therapeutic agent for inhibiting endothelial dysfunction.

机构信息

Cardiovascular Research Center, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, China; Key Laboratory of Cardiovascular Injury and Repair Medicine of Henan, Weihui, China.

出版信息

Biochem Pharmacol. 2023 Jul;213:115594. doi: 10.1016/j.bcp.2023.115594. Epub 2023 May 18.

DOI:10.1016/j.bcp.2023.115594

PMID:37207700

Abstract

Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of polycomb repressor complex 2 and plays important roles in endothelial cell homeostasis. EZH2 functionally methylates lysine 27 of histone H3 and represses gene expression through chromatin compaction. EZH2 mediates the effects of environmental stimuli by regulating endothelial functions, such as angiogenesis, endothelial barrier integrity, inflammatory signaling, and endothelial mesenchymal transition. Numerous studies have been conducted to determine the significance of EZH2 in endothelial function. The aim of this review is to provide a concise summary of the roles EZH2 plays in endothelial function and elucidate its therapeutic potential in cardiovascular diseases.

摘要

增强子结合锌指蛋白 2（EZH2）是多梳抑制复合物 2 的催化亚基，在血管内皮细胞稳态中发挥重要作用。EZH2 作为功能甲基化组蛋白 H3 赖氨酸 27 并通过染色质紧缩抑制基因表达。EZH2 通过调节血管生成、内皮屏障完整性、炎症信号和内皮间质转化等内皮功能来介导环境刺激的作用。已有大量研究旨在确定 EZH2 在血管内皮功能中的意义。本文旨在简要总结 EZH2 在血管内皮功能中的作用，并阐明其在心血管疾病治疗中的潜力。