Significance of the FGFR3 mutation in Chinese patients with bladder cancer.

BACKGROUND

Bladder cancer () is the 10th most common malignancy worldwide. The high recurrence rates of lead to significant treatment challenges. With the development of molecular biology techniques, research has shown that gene abnormalities are closely related to the occurrence and development of . This study analyzed the detection results of gene mutations in the tissue samples of patients and explored the relationship between fibroblast growth factor receptor 3 () and the prognosis and recurrence of .

METHODS

This study examined 82 Chinese patients with BC. Of these patients, 34 underwent radical cystectomy (), and 48 underwent transurethral resection with intravesical instillation. In addition, multi-gene panel targeted next-generation sequencing () of the samples was performed.

RESULTS

The mutational spectra revealed that was the most common base substitution. Single nucleotide polymorphism () and deletion () were the common variant types in our cohort. The top 10 mutant genes were (37%), (35%), (34%), (34%), (32%), (27%), (27%), (24%), (23%), and (18%). mutations were detected more frequently in non-muscle-invasive bladder cancer (stages 0a, I) patients than in muscle-invasive bladder cancer (stage II, III, and IV) patients. The top 3 altered types of were p.Ser249Cys, p.Tyr375Cys, and p.Arg248Cys.

CONCLUSIONS

This study examined the mutated types and frequency of and the prognosis of Chinese patients with mutations. We hope that our findings will enable clinical individualization strategies for patients to be optimized.