Department of Chemistry, Changu Kana Thakur A.C.S. College, New panvel(Autonomous), New Panvel, 410206, University of Mumbai, Maharashtra, India; Department of Chemistry, G. M. Vedak College of Science, Tala-Raigad, 402111, Maharashtra, India.
Department of Chemistry Doshi Vakil Arts and G.C.U.B. Science and Commerce College, Goregaon, Raigad, 402103, Maharashtra, India.
Eur J Med Chem. 2023 Oct 5;258:115549. doi: 10.1016/j.ejmech.2023.115549. Epub 2023 Jun 8.
Since the last decade, research on quinoline Schiff base metal complexes has risen substantially due to their versatile applications across many significant fields. Schiff bases are also known as azomethines, aldimines, and imines. Quinoline Schiff base-derived metal complexes are intriguing to study topics. These complexes are employed in biological, analytical, and catalytic fields. Researchers have found that Schiff bases are more biologically active when coordinated with metal ions. Research in the biological sciences has shown that heterocyclic compounds like quinoline and its derivatives are important. Because of their broad spectrum of activity, quinoline derivatives have been discovered to be effective therapeutic agents for various disorders. Even though various classical synthetic pathways mentioned in the literature are still in use, there is an urgent need for a new, more effective method that is safer for the environment, has a higher yield, generates less hazardous waste, and is easier to use. This highlights the critical need for a safe, eco-friendly approach to quinoline scaffold synthesis. This review focuses exclusively on Schiff base metal complexes derived from quinoline, fabricated and studied in the past ten years, and having anticancer, antibacterial, antifungal, antioxidant, antidiabetic, antiproliferative, DNA-intercalation, and cytotoxic activities.
近十年来,由于喹啉席夫碱金属配合物在许多重要领域的广泛应用,其研究有了实质性的增长。席夫碱也被称为亚胺、醛亚胺和亚胺。研究喹啉席夫碱衍生的金属配合物是一个有趣的课题。这些配合物在生物、分析和催化领域都有应用。研究人员发现,当金属离子与席夫碱配位时,其具有更高的生物活性。生物科学的研究表明,杂环化合物如喹啉及其衍生物很重要。由于其广泛的活性,已发现喹啉衍生物是治疗各种疾病的有效治疗剂。尽管文献中提到的各种经典合成途径仍在使用,但迫切需要一种新的、更有效的方法,这种方法对环境更安全,产率更高,产生的危险废物更少,使用更方便。这突出表明需要一种安全、环保的方法来合成喹啉支架。这篇综述仅关注过去十年中合成并研究过的、具有抗癌、抗菌、抗真菌、抗氧化、抗糖尿病、抗增殖、DNA 嵌入和细胞毒性活性的喹啉席夫碱金属配合物。