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肠道微生物代谢产物及其对人类健康的影响。

Gut microbial metabolites and its impact on human health.

作者信息

Rahman Shahrose, O'Connor Amber L, Becker Sarah L, Patel Ranish K, Martindale Robert G, Tsikitis Vassiliki Liana

机构信息

Department of Surgery, Oregon Health and Science University, Portland, OR, USA.

出版信息

Ann Gastroenterol. 2023 Jul-Aug;36(4):360-368. doi: 10.20524/aog.2023.0809. Epub 2023 May 29.

Abstract

One of the primary methods by which the gut microbiome interacts with its host is through the interactions that occur through the production of the metabolites produced, either directly, or indirectly, through microbial metabolism. Decades of research has demonstrated that these metabolic products play a vital role in human health, either for its benefit or detriment. This review article highlights the main metabolites produced by the interactions between diet and the gut microbiome, bile acids and the gut microbiome, and products produced by the gut microbiome alone. Additionally, this article reviews the literature on the effects that these metabolites play on human health.

摘要

肠道微生物群与其宿主相互作用的主要方式之一是通过微生物代谢直接或间接产生的代谢产物所发生的相互作用。数十年的研究表明,这些代谢产物对人类健康起着至关重要的作用,无论是有益还是有害。这篇综述文章重点介绍了饮食与肠道微生物群相互作用、胆汁酸与肠道微生物群相互作用以及仅由肠道微生物群产生的产物所产生的主要代谢产物。此外,本文还综述了关于这些代谢产物对人类健康影响的文献。

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