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乳腺和妇科癌症中的黄酮醇类化合物:系统评价。

Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review.

机构信息

Department of Immunology and Serology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.

Silesia LabMed: Centre for Research and Implementation, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.

出版信息

Nutrients. 2023 Jun 28;15(13):2938. doi: 10.3390/nu15132938.

Abstract

The consumption of foods that are rich in phenolic compounds has chemopreventive effects on many cancers, including breast cancer, ovarian cancer, and endometrial cancer. A wide spectrum of their health-promoting properties such as antioxidant, anti-inflammatory, and anticancer activities, has been demonstrated. This paper analyzes the mechanisms of the anticancer action of selected common flavonols, including kemferol, myricetin, quercetin, fisetin, galangin, isorhamnetin, and morin, in preclinical studies, with particular emphasis on in vitro studies in gynecological cancers and breast cancer. In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.

摘要

富含酚类化合物的食物的消费对许多癌症具有化学预防作用,包括乳腺癌、卵巢癌和子宫内膜癌。已经证明了它们具有广泛的促进健康的特性,如抗氧化、抗炎和抗癌活性。本文分析了选定的常见类黄酮,包括山奈酚、杨梅素、槲皮素、根皮素、高良姜素、异鼠李素和桑色素,在临床前研究中的抗癌作用机制,特别强调妇科癌症和乳腺癌的体外研究。这些化合物将来可能在妇科癌症和乳腺癌的预防和治疗中得到应用,但这需要进一步的、更先进的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d29/10346890/bb4e449d519f/nutrients-15-02938-g001.jpg

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