Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Brazil.
Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife 50670-901, Brazil.
Biomolecules. 2023 Jul 18;13(7):1144. doi: 10.3390/biom13071144.
In this review, we provide an overview of the current understanding of the main mechanisms of pharmacological action of essential oils and their components in various biological systems. A brief introduction on essential oil chemistry is presented to better understand the relationship of chemical aspects with the bioactivity of these products. Next, the antioxidant, anti-inflammatory, antitumor, and antimicrobial activities are discussed. The mechanisms of action against various types of viruses are also addressed. The data show that the multiplicity of pharmacological properties of essential oils occurs due to the chemical diversity in their composition and their ability to interfere with biological processes at cellular and multicellular levels via interaction with various biological targets. Therefore, these natural products can be a promising source for the development of new drugs.
在这篇综述中,我们概述了目前对精油及其成分在各种生物系统中的主要药理作用机制的理解。简要介绍了精油化学,以更好地理解化学方面与这些产品生物活性的关系。接下来,讨论了抗氧化、抗炎、抗肿瘤和抗菌活性。还讨论了针对各种类型病毒的作用机制。数据表明,精油的多种药理特性是由于其组成的化学多样性以及它们通过与各种生物靶标相互作用在细胞和多细胞水平上干扰生物过程的能力所致。因此,这些天然产物可能是开发新药的有前途的来源。