Division of Pulmonary and Sleep Medicine, Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Pulmonary Medicine, Department of Pediatrics, Virginia Commonwealth University and Children's Hospital of Richmond at VCU, Richmond, VA, USA.
Clin Chest Med. 2023 Sep;44(3):555-573. doi: 10.1016/j.ccm.2023.03.011. Epub 2023 May 8.
This review summarizes the evidence of health disparities in cystic fibrosis (CF), an autosomal recessive genetic disorder with substantial variation in disease progression and outcomes. We review disparities by race, ethnicity, socioeconomic status, geographic location, gender identity, or sexual orientation documented in the literature. We outline the mechanisms that generate and perpetuate such disparities across levels and domains of influence and assess the implications of this evidence. We then recommend strategies for improving equity in CF outcomes, drawing on recommendations for the general population and considering approaches specific to people living with CF.
这篇综述总结了囊性纤维化 (CF) 中的健康差异证据,CF 是一种常染色体隐性遗传疾病,其疾病进展和结果存在很大差异。我们综述了文献中记录的按种族、民族、社会经济地位、地理位置、性别认同或性取向划分的差异。我们概述了在各级和各领域产生和延续这种差异的机制,并评估了这一证据的意义。然后,我们建议了一些策略来改善 CF 结果的公平性,借鉴了针对一般人群的建议,并考虑了针对 CF 患者的具体方法。