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Heartbreakers: innate sensors ZBP1 and cGAS linked to cardiotoxicity.

作者信息

Chen Wen, Kanneganti Thirumala-Devi

机构信息

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

出版信息

Cell Res. 2023 Dec;33(12):902-903. doi: 10.1038/s41422-023-00861-9.

Abstract
摘要

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本文引用的文献

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Cell. 2023 Jul 6;186(14):3013-3032.e22. doi: 10.1016/j.cell.2023.05.039. Epub 2023 Jun 22.
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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Cell Rep. 2021 Oct 19;37(3):109858. doi: 10.1016/j.celrep.2021.109858.
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AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Nature. 2021 Sep;597(7876):415-419. doi: 10.1038/s41586-021-03875-8. Epub 2021 Sep 1.
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