生命早期营养与成人期结局。
Early-life nutrition and adult-life outcomes.
机构信息
Department of Pediatrics, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil.
Department of Neuropediatrics, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil.
出版信息
J Pediatr (Rio J). 2024 Mar-Apr;100 Suppl 1(Suppl 1):S4-S9. doi: 10.1016/j.jped.2023.08.007. Epub 2023 Oct 6.
OBJECTIVES
To verify the association between early-life nutrition and chronic adult diseases.
DATA SOURCES
Medline, Embase, Cochrane Database, and Lilacs.
SUMMARY OF FINDS
The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that a mismatch between early-life circumstances and later-life situations may have an impact on chronic diseases. In this review, the authors emphasize the research supporting the impact of early nutrition on the origins of adult height, obesity and metabolic syndrome, type 2 diabetes mellitus, cardiovascular diseases, and reproductive outcomes.
CONCLUSION
Even though this is a new topic and there are still many research questions to be answered, there is strong evidence that both deficiency and excess nutrition in early life can cause epigenetic changes that have effects that last a lifetime and contribute to the development of chronic diseases. Public health efforts to protect adults from getting chronic diseases should focus on nutrition in the first 1000 days of life, from conception to the end of the second year of life.
目的
验证生命早期营养与慢性成人疾病之间的关联。
资料来源
Medline、Embase、Cochrane 数据库和 Lilacs。
研究结果概要
健康与疾病的发育起源（DOHaD）假说假设，生命早期环境与后期环境之间的不匹配可能对慢性疾病产生影响。在这篇综述中，作者强调了支持早期营养对成年身高、肥胖和代谢综合征、2 型糖尿病、心血管疾病和生殖结局起源影响的研究。
结论
尽管这是一个新的主题，仍有许多研究问题需要回答，但有强有力的证据表明，生命早期的营养不足和过剩都可能导致表观遗传变化，这些变化会持续一生，并导致慢性疾病的发展。保护成年人免受慢性疾病影响的公共卫生工作应侧重于生命最初 1000 天的营养，即从受孕到生命第二年结束。
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