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欧洲核医学中使用的新型放射性核素:我们目前的状况以及未来的发展方向?

Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go?

作者信息

Radzina Maija, Saule Laura, Mamis Edgars, Koester Ulli, Cocolios Thomas Elias, Pajuste Elina, Kalnina Marika, Palskis Kristaps, Sawitzki Zoe, Talip Zeynep, Jensen Mikael, Duchemin Charlotte, Leufgen Kirsten, Stora Thierry

机构信息

University of Latvia, Riga, Latvia.

CERN, Geneva, Switzerland.

出版信息

EJNMMI Radiopharm Chem. 2023 Oct 12;8(1):27. doi: 10.1186/s41181-023-00211-5.

Abstract

BACKGROUND

In order to support the ongoing research across Europe to facilitate access to novel radionuclides, the PRISMAP consortium (European medical radionuclides programme) was established to offer the broadest catalog of non-conventional radionuclides for medical and translational research. The aim of this article is to introduce readers with current status of novel radionuclides in Europe.

MAIN BODY

A consortium questionnaire was disseminated through the PRISMAP consortium and user community, professional associations and preclinical/clinical end users in Europe and the current status of clinical end-users in nuclear medicine were identified. A total of 40 preclinical/clinical users institutions took part in the survey. Clinical end users currently use the following radionuclides in their studies: Lu,  Ga, In, Y, other alpha emitters, Ac, Cu and Terbium isotopes. Radionuclides that would be of interest for users within the next 2-5 years are Cu, Terbium radionuclide "family" and alpha emitters, such as Ac.

CONCLUSIONS

Thanks to a questionnaire distributed by the PRISMAP consortium, the current status and needs of clinical end-users in nuclear medicine were identified.

摘要

背景

为了支持欧洲正在进行的促进获取新型放射性核素的研究,PRISMAP联盟(欧洲医用放射性核素计划)成立,旨在为医学和转化研究提供最广泛的非常规放射性核素目录。本文旨在向读者介绍欧洲新型放射性核素的现状。

正文

通过PRISMAP联盟以及欧洲的用户社区、专业协会和临床前/临床终端用户发放了一份联盟调查问卷,确定了核医学临床终端用户的现状。共有40个临床前/临床用户机构参与了调查。临床终端用户目前在其研究中使用以下放射性核素:镥、镓、铟、钇、其他α发射体、锕、铜和铽同位素。未来2至5年内用户感兴趣的放射性核素是铜、铽放射性核素“家族”以及α发射体,如锕。

结论

通过PRISMAP联盟发放的调查问卷,确定了核医学临床终端用户的现状和需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df10/10570248/dcb2886298f3/41181_2023_211_Fig1_HTML.jpg

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