血液白细胞 DNA 甲基化与儿童中期至晚期持续性注意力的关联。
Associations between blood leukocyte DNA methylation and sustained attention in mid-to-late childhood.
机构信息
Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Nutritional Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Epigenomics. 2023 Oct;15(19):965-981. doi: 10.2217/epi-2023-0169. Epub 2023 Nov 9.
To identify associations between DNA methylation (DNAm) across the epigenome and symptoms related to attention-deficit/hyperactivity disorder in a population of Hispanic children. Among 517 participants in the ELEMENT study aged 9-18 years, we conducted an epigenome-wide association study examining associations between blood leukocyte DNAm and performance on the Conners' continuous performance test (CPT3). DNAm at loci in or near , and and functional enrichment for gene pathways pertaining to ferroptosis, inflammation, immune response and neurotransmission were significantly related to CPT3 scores. DNAm was associated with CPT3 performance. Further analysis is warranted to understand how these genes and enriched pathways contribute to attention-deficit/hyperactivity disorder.
为了确定西班牙裔儿童人群中整个表观基因组的 DNA 甲基化 (DNAm) 与注意力缺陷多动障碍相关症状之间的关联。在 ELEMENT 研究的 517 名 9-18 岁参与者中，我们进行了一项全基因组关联研究，研究血液白细胞 DNAm 与康纳斯连续绩效测试 (CPT3) 表现之间的关联。位于或附近的基因座处的 DNAm 和 以及与铁死亡、炎症、免疫反应和神经传递相关的基因途径的功能富集与 CPT3 评分显著相关。DNAm 与 CPT3 表现相关。需要进一步分析以了解这些基因和富集途径如何导致注意力缺陷多动障碍。
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