修饰策略对肽/蛋白质生物活性的影响。
Effect of Modification Strategies on the Biological Activity of Peptides/Proteins.
机构信息
School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
出版信息
Chembiochem. 2024 Feb 1;25(3):e202300481. doi: 10.1002/cbic.202300481. Epub 2023 Dec 8.
Covalent attachment of biologically active peptides/proteins with functional moieties is an effective strategy to control their biodistribution, pharmacokinetics, enzymatic digestion, and toxicity. This review focuses on the characteristics of different modification strategies and their effects on the biological activity of peptides/proteins and illustrates their relevant applications and potential.
将生物活性肽/蛋白质与功能基团共价连接是控制其生物分布、药代动力学、酶解和毒性的有效策略。本文主要介绍了不同修饰策略的特点及其对肽/蛋白质生物活性的影响，并举例说明了它们的相关应用和潜力。
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