脑衰老和神经退行性变中的细胞衰老。
Cellular senescence in brain aging and neurodegeneration.
机构信息
European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen, Antonius Deusinglaan 1, 9715RA, Groningen, the Netherlands; School of Sciences, Health and Life, Pontifical Catholic University of Rio Grande do Sul, Ipiranga Avenue, 6681, 90619-900 Porto Alegre, Brazil.
Department of Biomedical Sciences of Cells and Systems, section Molecular Neurobiology, University Medical Center Groningen (UMCG), University of Groningen, Antonius Deusinglaan 1, 9715RA Groningen, the Netherlands; Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusiglaan 1, 9713AV Groningen, the Netherlands.
出版信息
Ageing Res Rev. 2024 Jan;93:102141. doi: 10.1016/j.arr.2023.102141. Epub 2023 Nov 27.
Cellular senescence is a state of terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells naturally accumulate during aging and at sites of age-related pathologies. Here, we discuss the recent advances in understanding the accumulation of senescent cells in brain aging and disorders. Here we highlight the phenotypical heterogeneity of different senescent brain cell types, highlighting the potential importance of subtype-specific features for physiology and pathology. We provide a comprehensive overview of various senescent cell types in naturally occurring aging and the most common neurodegenerative disorders. Finally, we critically discuss the potential of adapting senotherapeutics to improve brain health and reduce pathological progression, addressing limitations and future directions for application and development.
细胞衰老是一种与各种大分子变化和高分泌表型相关的终末细胞周期停滞状态。在大脑中，衰老细胞在衰老过程中以及在与年龄相关的病变部位自然积累。在这里，我们讨论了近年来对理解大脑衰老和疾病中衰老细胞积累的认识进展。在这里，我们强调了不同衰老脑细胞类型的表型异质性，突出了亚型特异性特征对生理学和病理学的潜在重要性。我们全面概述了自然发生的衰老和最常见的神经退行性疾病中的各种衰老细胞类型。最后，我们批判性地讨论了适应衰老治疗以改善大脑健康和减少病理进展的潜力，解决了应用和发展的局限性和未来方向。
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