帕金森病与肠道微生物群：从临床到机制和治疗研究。
Parkinson's disease and gut microbiota: from clinical to mechanistic and therapeutic studies.
机构信息
Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, China.
出版信息
Transl Neurodegener. 2023 Dec 15;12(1):59. doi: 10.1186/s40035-023-00392-8.
Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. The typical symptomatology of PD includes motor symptoms; however, a range of nonmotor symptoms, such as intestinal issues, usually occur before the motor symptoms. Various microorganisms inhabiting the gastrointestinal tract can profoundly influence the physiopathology of the central nervous system through neurological, endocrine, and immune system pathways involved in the microbiota-gut-brain axis. In addition, extensive evidence suggests that the gut microbiota is strongly associated with PD. This review summarizes the latest findings on microbial changes in PD and their clinical relevance, describes the underlying mechanisms through which intestinal bacteria may mediate PD, and discusses the correlations between gut microbes and anti-PD drugs. In addition, this review outlines the status of research on microbial therapies for PD and the future directions of PD-gut microbiota research.
帕金森病（PD）是最常见的神经退行性疾病之一。PD 的典型症状包括运动症状；然而，一系列非运动症状，如肠道问题，通常在运动症状之前出现。居住在胃肠道中的各种微生物可以通过涉及微生物群-肠道-大脑轴的神经系统、内分泌和免疫系统途径，深刻地影响中枢神经系统的病理生理学。此外，大量证据表明肠道微生物群与 PD 密切相关。本综述总结了 PD 中微生物变化的最新发现及其临床相关性，描述了肠道细菌可能介导 PD 的潜在机制，并讨论了肠道微生物与抗 PD 药物之间的相关性。此外，本综述概述了 PD 微生物治疗研究的现状和 PD-肠道微生物组研究的未来方向。
Zotero 插件