RNA 结合蛋白在心血管疾病中的功能。
Functions of RNA-Binding Proteins in Cardiovascular Disease.
机构信息
Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
出版信息
Cells. 2023 Dec 8;12(24):2794. doi: 10.3390/cells12242794.
Gene expression is under tight regulation from the chromatin structure that regulates gene accessibility by the transcription machinery to protein degradation. At the transcript level, this regulation falls on RNA-binding proteins (RBPs). RBPs are a large and diverse class of proteins involved in all aspects of a transcript's lifecycle: splicing and maturation, localization, stability, and translation. In the past few years, our understanding of the role of RBPs in cardiovascular diseases has expanded. Here, we discuss the general structure and function of RBPs and the latest discoveries of their role in pulmonary and systemic cardiovascular diseases.
基因表达受到严格调控，从调节转录机制基因可及性的染色质结构到蛋白质降解。在转录水平上，这种调控取决于 RNA 结合蛋白 (RBP)。RBP 是一大类具有多样性的蛋白质，涉及转录本生命周期的各个方面：剪接和成熟、定位、稳定性和翻译。在过去的几年中，我们对 RBP 在心血管疾病中的作用的理解已经扩展。在这里，我们讨论 RBP 的一般结构和功能，以及它们在肺和全身心血管疾病中的作用的最新发现。
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