Department of Medical Laboratory Science, Kampala International University, Kampala, Uganda.
School of Nursing Science, Kampala International University, Kampala, Uganda.
Medicine (Baltimore). 2024 Jan 19;103(3):e36905. doi: 10.1097/MD.0000000000036905.
Breast cancer remains a complex and prevalent health concern affecting millions of individuals worldwide. This review paper presents a comprehensive analysis of the multifaceted landscape of breast cancer, elucidating the diverse spectrum of risk factors contributing to its occurrence and exploring advancements in diagnostic methodologies. Through an extensive examination of current literature, various risk factors have been identified, encompassing genetic predispositions such as BRCA mutations, hormonal influences, lifestyle factors, and reproductive patterns. Age, family history, and environmental factors further contribute to the intricate tapestry of breast cancer etiology. Moreover, this review delineates the pivotal role of diagnostic tools in the early detection and management of breast cancer. Mammography, the cornerstone of breast cancer screening, is augmented by emerging technologies like magnetic resonance imaging and molecular testing, enabling improved sensitivity and specificity in diagnosing breast malignancies. Despite these advancements, challenges persist in ensuring widespread accessibility to screening programs, particularly in resource-limited settings. In conclusion, this review underscores the importance of understanding diverse risk factors in the development of breast cancer and emphasizes the critical role of evolving diagnostic modalities in enhancing early detection. The synthesis of current knowledge in this review aims to contribute to a deeper comprehension of breast cancer's multifactorial nature and inform future directions in research, screening strategies, and preventive interventions.
乳腺癌仍然是一个复杂且普遍存在的健康问题,影响着全球数以百万计的个体。本文综述对乳腺癌的多方面进行了全面分析,阐明了导致其发生的多种风险因素,并探讨了诊断方法学的进展。通过对现有文献的广泛研究,已经确定了多种风险因素,包括 BRCA 突变等遗传易感性、激素影响、生活方式因素和生殖模式。年龄、家族史和环境因素进一步加剧了乳腺癌病因的复杂性。此外,本文还阐述了诊断工具在乳腺癌早期检测和管理中的关键作用。乳腺 X 线摄影作为乳腺癌筛查的基石,通过磁共振成像和分子检测等新兴技术得到了增强,提高了诊断乳腺癌的灵敏度和特异性。尽管取得了这些进展,但在确保广泛获得筛查计划方面仍然存在挑战,特别是在资源有限的环境中。总之,本文强调了理解乳腺癌发生的多种风险因素的重要性,并强调了不断发展的诊断方法在提高早期检测方面的关键作用。本文综述的综合知识旨在促进对乳腺癌多因素性质的更深入理解,并为未来的研究、筛查策略和预防干预提供信息。