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[2021/2022学年巴伐利亚州小学和特殊需求学校的PCR混合检测结果:新冠疫情期间面对面教学中的哨点监测]

[Results of PCR Pool Testing In Primary and Special Needs Schools In Bavaria For The School Year 2021/2022: Sentinel Surveillance In Face-To-Face Teaching During The Sars-CoV-2 Pandemic].

作者信息

Loidl Verena, Klinc Christina, Fusiak Jakub, Crispin Alexander, Hoffmann Verena Sophia, Nennstiel-Ratzel Uta, Mansmann Ulrich

机构信息

Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Medizinische Fakultät, München, Germany.

Pettenkofer School of Public Health, Ludwig-Maximilians-Universität München, Medizinische Fakultät, München, Germany.

出版信息

Gesundheitswesen. 2024 Mar;86(3):237-246. doi: 10.1055/a-2216-0139. Epub 2024 Feb 5.

Abstract

In the school years 2019/20 and 2020/21, children were physically, psychologically, and socially stressed by school closures caused by the SARS-CoV-2 pandemic. To ensure attendance with optimal infection protection, PCR pool testing was conducted during the 2021/22 school year at Bavarian elementary schools and schools for pupils with special needs for timely detection of SARS-CoV-2 infection. This study analyzes the results of PCR pool testing over time stratified by region, school type, and age of children. The data were obtained from classes in elementary and special needs schools, involving pupils aged 6 to 11 years, who participated in the Bavaria-wide PCR pool testing from 09/20/21 to 04/08/22. Samples were collected twice weekly, consisting of PCR pool samples and individual PCR samples, which were only evaluated in case of a positive pool test. A class was considered positive if at least one individual sample from that class was positive within a calendar week (CW). A school (class) was considered to be infection-prone if three or more classes in that school (students in that class) were positive within a CW. The data included 2,430 elementary schools (339 special needs schools) with 23,021 (2,711) classes and 456,478 (29,200) children. A total of 1,157,617 pools (of which 3.37% were positive) and 724,438 individual samples (6.76% positive) were analyzed. Larger schools exhibited higher PR compared to smaller schools. From January 2022, the Omicron variant led to a massive increase in PR across Bavaria. The incidence rates per 100,000 person-weeks within the individual school samples were significantly lower than the concurrently reported age-specific and general infection incidences in the overall Bavarian population. PCR pool testing revealed relatively few positive pools, with an average of four children per one hundred pools testing positive. Schools and classes were rarely considered infection-prone, even during periods of high incidences outside of schools. The combination of PCR pool testing and hygiene measures allowed for a largely safe in-person education for pupils in primary and special needs schools in the school year 2021/22.

摘要

在2019/20学年和2020/21学年,儿童因严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行导致学校关闭而在身体、心理和社交方面承受压力。为确保学生到校上课并提供最佳感染防护,巴伐利亚州的小学和特殊需求学校在2021/22学年进行了聚合酶链反应(PCR)混合检测,以便及时发现SARS-CoV-2感染情况。本研究分析了按地区、学校类型和儿童年龄分层的不同时间段的PCR混合检测结果。数据来自小学和特殊需求学校的班级,涉及6至11岁的学生,他们于2021年9月20日至2022年4月8日参与了巴伐利亚州范围内的PCR混合检测。每周采集两次样本,包括PCR混合样本和单独的PCR样本,仅在混合检测呈阳性时才对单独样本进行评估。如果在一个日历周(CW)内该班级至少有一个单独样本呈阳性,则该班级被视为阳性。如果一所学校(该班级的学生)在一个CW内有三个或更多班级呈阳性,则该学校(班级)被视为易感染学校。数据包括2430所小学(339所特殊需求学校)、23021个(2711个)班级以及456478名(29200名)儿童。共分析了1157617份混合样本(其中3.37%呈阳性)和724438份单独样本(6.76%呈阳性)。规模较大的学校与规模较小的学校相比,阳性率更高。自2022年1月起,奥密克戎变异株导致巴伐利亚州的阳性率大幅上升。各学校样本中每10万人周的发病率显著低于巴伐利亚州总体人群中同时报告的特定年龄和总体感染发病率。PCR混合检测显示阳性混合样本相对较少,平均每100份样本中有4名儿童检测呈阳性。即使在学校外发病率较高的时期,学校和班级也很少被视为易感染学校。PCR混合检测与卫生措施相结合,使得2021/22学年小学和特殊需求学校的学生能够在很大程度上安全地进行面授教育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ccd/11301650/7b82344df97a/10-1055-a-2216-0139-i2022-12-1772-0001.jpg

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