一种蝎源肽的体外和体内抗白色念珠菌活性
In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide.
作者信息
Li Zhongjie, Shui Yingbin, Wang Huayi, Li Shasha, Deng Bo, Zhang Wenlu, Gao Shegan, Zhao Lingyu
机构信息
Institute of Genetics and Developmental Biology, Translational Medicine Institute, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710049, China.
Microbial Pathogen and Anti-Infection Research Group, School of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, China.
出版信息
Probiotics Antimicrob Proteins. 2025 Jun;17(3):1615-1623. doi: 10.1007/s12602-024-10233-3. Epub 2024 Feb 19.
The increasing infection and drug resistance frequency has encouraged the exploration of new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion antimicrobial peptide derivative, effectively inhibit the growth of C. albicans. CT-K3K7 killed C. albicans cells in a dose-dependent manner, mainly by damaging the plasma membrane. CT-K3K7 could also disrupt the nucleus and interact with nucleic acid. Moreover, CT-K3K7 induced C. albicans cells necrosis via a reactive oxygen species (ROS)-related pathway. Furthermore, CT-K3K7 inhibited the hyphal and biofilm formation of C. albicans. In the mouse skin subcutaneous infection model, CT-K3K7 significantly prevented skin abscess formation and reduced the number of C. albicans cells recovered from the infection area. Taken together, CT-K3K7 has the potential to be a therapeutic for C. albicans skin infections.
感染及耐药频率的不断增加促使人们探索新型有效的抗白色念珠菌药物。在本研究中，蝎毒抗菌肽衍生物CT-K3K7能有效抑制白色念珠菌的生长。CT-K3K7以剂量依赖的方式杀死白色念珠菌细胞，主要是通过损伤细胞膜。CT-K3K7还能破坏细胞核并与核酸相互作用。此外，CT-K3K7通过活性氧（ROS）相关途径诱导白色念珠菌细胞坏死。此外，CT-K3K7抑制白色念珠菌的菌丝和生物膜形成。在小鼠皮肤皮下感染模型中，CT-K3K7显著预防了皮肤脓肿的形成，并减少了从感染区域回收的白色念珠菌细胞数量。综上所述，CT-K3K7有潜力成为治疗白色念珠菌皮肤感染的药物。
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