机械敏感离子通道Piezo1在骨重塑中的作用。
The role of mechanically sensitive ion channel Piezo1 in bone remodeling.
作者信息
Du Yugui, Xu Bowen, Li Quiying, Peng Chuhan, Yang Kai
机构信息
Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China.
出版信息
Front Bioeng Biotechnol. 2024 Feb 8;12:1342149. doi: 10.3389/fbioe.2024.1342149. eCollection 2024.
Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing various physical forces, such as tension, osmotic pressure, and shear force. Piezo1 mediates mechanosensory transduction in different organs and tissues, including its role in maintaining bone homeostasis. This review aimed to summarize the function and possible mechanism of Piezo1 in the mechanical receptor cells in bone tissue. We found that it is a potential therapeutic target for the treatment of bone diseases.
Piezo1（2010年）被鉴定为一种机械激活的阳离子通道，能够感知各种物理力，如张力、渗透压和剪切力。Piezo1在不同器官和组织中介导机械感觉转导，包括其在维持骨稳态中的作用。本综述旨在总结Piezo1在骨组织机械感受器细胞中的功能及可能机制。我们发现它是治疗骨疾病的一个潜在治疗靶点。
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