脂质体：作为癌症治疗递送系统的组成、制备技术及最新进展
Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy.
作者信息
Liga Sergio, Paul Cristina, Moacă Elena-Alina, Péter Francisc
机构信息
Biocatalysis Group, Department of Applied Chemistry and Engineering of Organic and Natural Compounds, Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timișoara, Carol Telbisz 6, 300001 Timișoara, Romania.
Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, 2nd Eftimie Murgu Square, 300041 Timișoara, Romania.
出版信息
Pharmaceutics. 2024 Feb 4;16(2):223. doi: 10.3390/pharmaceutics16020223.
Niosomes are vesicular nanocarriers, biodegradable, relatively non-toxic, stable, and inexpensive, that provide an alternative for lipid-solid carriers (e.g., liposomes). Niosomes may resolve issues related to the instability, fast degradation, bioavailability, and insolubility of different drugs or natural compounds. Niosomes can be very efficient potential systems for the specific delivery of anticancer, antioxidant, anti-inflammatory, antimicrobial, and antibacterial molecules. This review aims to present an overview of their composition, the most common formulation techniques, as well as of recent utilizations as delivery systems in cancer therapy.
非离子表面活性剂泡囊是一种囊泡状纳米载体，具有生物可降解性、相对无毒、稳定性好且成本低廉的特点，为脂质固体载体（如脂质体）提供了一种替代选择。非离子表面活性剂泡囊可以解决与不同药物或天然化合物的不稳定性、快速降解、生物利用度和不溶性相关的问题。非离子表面活性剂泡囊对于抗癌、抗氧化、抗炎、抗菌和抗微生物分子的特异性递送可能是非常有效的潜在系统。本综述旨在概述其组成、最常见的制剂技术，以及作为癌症治疗递送系统的最新应用。
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